What is Ara-290 (Cibinetide) ? Is an 11-amino-acid synthetic peptide derived from erythropoietin that selectively activates the innate repair receptor (IRR) without stimulating red-blood-cell production. Widely used in preclinical models of neuroinflammation, organ protection, and metabolic regulation, ARA-290 offers precise IRR engagement and robust cytoprotective signaling.
Mechanism of Action
it acts as a “molecular switch” that changes a pro-inflammatory tissue environment into a healing environment, it is heavily studied for its potential to treat a wide variety of systemic inflammatory and autoimmune conditions without stimulating the bone marrow.
The Science
- The Innate Repair Receptor (IRR): While normal EPO binds to receptors that stimulate red blood cell growth (which can thicken the blood), ARA-290 selectively activates the IRR. The IRR is typically only expressed on cells undergoing stress or inflammation, making ARA-290 a highly targeted, anti-inflammatory, and anti-apoptotic (cell-death-preventing) compound.
- Pain Modulation and Nerve Repair: Clinical research has highlighted ARA-290’s ability to reduce neuropathic pain—especially in conditions like small fiber neuropathy often associated with sarcoidosis. Studies show it helps repair and regenerate small nerve fibers (as measured in the cornea and skin).
- TRPV1 Antagonism: In addition to its tissue-repairing pathway, ARA-290 acts as an antagonist to the TRPV1 receptor, which helps block capsaicin-evoked hypersensitivity and neuropathic pain signaling.
Purity & Quality
• ≥99% purity verified via HPLC
• Certificate of Analysis included
Storage: Store in a cool, dry place, protected from light
Intended Use
Can be used in studies to reduce inflammation, alleviate chronic neuropathic pain (such as diabetic nerve pain), and promote tissue healing without stimulating red blood cell production
Terms of Sale
All sales are final. Users should follow professional guidance for dosing and application.
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